Sequential Birch Reduction-Allylation and Cope Rearrangement of O-Anisic Acid Derivatives
نویسندگان
چکیده
A new method for the construction of quaternary centers on cycloalkane rings is reported. The Cope rearrangement of 4methyl-2-allyl-2-(N-pyrrolidinyl)-carboxamide-3-cyclohexenone yields 4-methyl-4allyl-2-(N-pyrrolidinyl)-carboxamide-2-cyclohexenone in high yield. The rearrangement substrates are easily generated from Birch reduction-allylation of o-anisic acid derivatives. © 2012 Elsevier Science. All rights reserved
منابع مشابه
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تاریخ انتشار 2015